Analytical Data
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Gene name
CADM1/IGSF4A
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简介
The CADM1/IGSF4A protein is an important mediator of cell-cell adhesion.It forms homodimers and interacts with CADM3 and NECTIN3.CADM1/IGSF4A Protein, Human (HEK293, His) is the recombinant human-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CRTAM at 2 μg/mL (100 μL/well) can bind Biotinylated Human CADM1. The ED50 for this effect is 105.7 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Human CRTAM at 2 μg/mL (100 μL/well) can bind Biotinylated Human CADM1. The ED50 for this effect is 105.7 ng/mL.
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Alternative Names
Cell adhesion molecule 1; IgSF4; NECL-2; SynCAM; TSLC-1
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9BY67
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Expression Region
Q45-H374
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AA Sequence
QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDH
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Protein Length
Extracellular Domain
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Molecular Weight
60-95 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CADM1, also known as Cell Adhesion Molecule 1, and IGSF4A, an Immunoglobulin Superfamily member 4A, are crucial components in cellular adhesion and communication processes, particularly in the nervous system and immune responses. CADM1 is implicated in synaptic plasticity, neuronal development, and tumor suppression, while IGSF4A plays roles in regulating cell junctions and signaling pathways. The study of CADM1 and IGSF4A recombinant proteins has gained significant attention due to their potential applications in understanding various diseases, including cancer and neurodegenerative disorders. By producing and analyzing these recombinant proteins, researchers aim to elucidate their structural properties, functional mechanisms, and interactions with other cellular components. This research not only enhances our knowledge of cell adhesion and communication but also opens avenues for therapeutic interventions targeting CADM1 and IGSF4A in disease contexts. The insights gained from studying these proteins may lead to novel biomarker discoveries and strategies for drug development. Therefore, the exploration of CADM1/IGSF4A recombinant proteins holds promise for advancing biomedical science and improving treatment options for various pathologies.
