Analytical Data
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Gene name
TCTP/TPT1
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简介
TCTP/TPT1 is a multifunctional protein that plays a crucial role in cellular processes by participating in calcium binding and contributing to microtubule stabilization. As a negative regulator, it destabilizes TSC22D1, thereby inhibiting apoptosis. TCTP/TPT1 Protein, Human (HEK293, His) is the recombinant human-derived TCTP/TPT1 protein, expressed by HEK293 , with N-10*His labeled tag.
- Application
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Alternative Names
Translationally-controlled tumor protein; Fortilin; HRF; p23
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Species
Human
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Source
HEK293
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Tag
N-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13693
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Expression Region
M1-C172
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCTP (Tumor Protein Translationally Controlled 1), also known as TPT1, is a highly conserved protein that plays crucial roles in various cellular processes, including cell growth, differentiation, and apoptosis. It is implicated in tumorigenesis and is overexpressed in several types of cancer, making it a potential target for therapeutic intervention. Studies have shown that TCTP interacts with multiple cellular partners, influencing pathways related to signal transduction, stress response, and cell motility. The molecular mechanisms underlying its functions are of significant interest, particularly in relation to its role in cancer progression and metastasis. Research has increasingly focused on the structural characteristics of TCTP, revealing domains that facilitate its interactions with other proteins, as well as its involvement in critical cellular functions such as translation and stress response. Recombinant TCTP/TPT1 proteins have been developed to better understand its biochemical properties and interactions. By using these recombinant proteins in various assays, researchers aim to elucidate the functional roles of TCTP in health and disease, providing insights that could lead to novel therapeutic strategies for cancer and other disorders where TCTP is dysregulated. The advancement in recombinant protein technology has therefore paved the way for in-depth studies on TCTP, highlighting its importance as a biomarker and a potential therapeutic target in oncology. As such, continued research into TCTP/TPT1 not only enhances our understanding of fundamental biological processes but also opens up new avenues for targeted drug development.
