Analytical Data
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Gene name
HIST1H2AD
- Application
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Alternative Names
H2AFG; H2A/g; H2A.3; H2A Histone Family Member G
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20671
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Expression Region
Ser2~Lys130
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AD is a gene encoding a variant of histone H2A, which plays a crucial role in the structure and function of chromatin, the complex of DNA and proteins that organize genetic material in eukaryotic cells. Histones are integral for the regulation of gene expression, DNA replication, and repair processes. The study of HIST1H2AD has garnered attention due to its potential involvement in various biological and pathological processes, including cancer development, where aberrations in histone modifications can lead to altered gene expression patterns. Recent advances in proteomics and molecular biology techniques have enabled researchers to isolate and characterize the HIST1H2AD protein, revealing its contribution to chromatin dynamics and cellular responses to environmental stimuli. Understanding the functional implications of HIST1H2AD, particularly its role in modulating epigenetic landscapes, presents opportunities for novel therapeutic strategies in diseases characterized by dysregulated chromatin states. Investigations into the reconstitution of HIST1H2AD protein provide insights into histone variant functions and the intricate mechanisms governing chromatin architecture, which may pave the way for innovative approaches in epigenetic research and treatment. As a target of interest, HIST1H2AD serves as a promising avenue for uncovering the complexities of gene regulation and the development of interventions for diseases linked to chromatin dysfunction.
