Analytical Data
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Gene name
DDX23
- Application
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Alternative Names
Prp28; U5-100K; PRPF28; Asp-Glu-Ala-Asp Box Polypeptide 23; Probable ATP-dependent RNA helicase DDX23; 100 kDa U5 snRNP-specific protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BUQ8
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Expression Region
Ile422~Pro799
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Molecular Weight
46kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DDX23 is a member of the DEAD-box RNA helicase family, which plays crucial roles in various cellular processes, including mRNA processing, ribosome biogenesis, and gene expression regulation. Recent studies have highlighted DDX23's involvement in cancer development and progression, suggesting that it may act as a potential biomarker or therapeutic target for malignancies. The protein's unique ability to unwind RNA structures, coupled with its interactions with various RNA-binding proteins, positions it as a key player in maintaining RNA homeostasis within the cell. Understanding the structure, function, and regulation of DDX23 can provide insights into its biological significance and potential implications in diseases. The production of recombinant DDX23 protein allows for in-depth functional studies and structural analyses, which are essential for elucidating its mechanistic roles in RNA metabolism and its involvement in pathological conditions. Through this research, scientists aim to unveil the therapeutic possibilities of targeting DDX23 in cancer treatments and enhance our knowledge of RNA helicase functions in cellular physiology.
