Analytical Data
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Gene name
CDK2AP2
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简介
The CDK2AP2 protein is an important component of the NuRD complex and actively participates in chromatin remodeling. It inhibits the G1/S phase transition by inhibiting CDK2 and preventing the interaction of CDK2 with cyclin E or A. CDK2AP2 Protein, Human (HEK293, His) is the recombinant human-derived CDK2AP2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
rHuCyclin-dependent kinase 2-associated protein 2/CDK2AP2, His; Cyclin-dependent kinase 2-associated protein 2; CDK2-associated protein 2; DOC-1-related protein; DOC-1R; CDK2AP2; DOC1R
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75956
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Expression Region
M1-T126
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Protein Length
Full Length
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK2AP2 (Cyclin-Dependent Kinase 2-Associated Protein 2) is a regulatory protein that has garnered attention due to its role in cell cycle regulation and potential implications in cancer biology. This protein functions as an inhibitor of cyclin-dependent kinases, specifically CDK2, which is crucial for the transition from the G1 phase to the S phase of the cell cycle. Dysregulation of CDK2 activity has been associated with various types of cancers, making CDK2AP2 a candidate for further investigation in tumor biology. Recent studies have suggested that CDK2AP2 may exhibit tumor-suppressive properties, potentially through its ability to modulate cell proliferation and promote apoptosis in cancer cells. Furthermore, the expression levels of CDK2AP2 may serve as a biomarker for prognostic evaluations in some malignancies. The recombinant expression of CDK2AP2 in vitro enables researchers to explore its biochemical properties, interactions with other cell cycle regulatory proteins, and its overall impact on cellular function. Understanding the mechanisms through which CDK2AP2 exerts its effects may provide valuable insights into therapeutic targets for the treatment of cancer and other proliferative disorders. As research in this area continues to evolve, CDK2AP2 represents a promising avenue for the development of novel cancer therapies aimed at restoring normal cell cycle regulation.
