Analytical Data
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Gene name
RPTOR
- Application
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Alternative Names
KOG1; Mip1; Raptor; p150 target of rapamycin (TOR)-scaffold protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N122
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Expression Region
Asn1020~Arg1335
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Molecular Weight
37kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPTOR, or Regulatory-Associated Protein of mTOR, plays a pivotal role in the mechanistic target of rapamycin (mTOR) signaling pathway, which is crucial for cellular growth, proliferation, and metabolism. The mTOR pathway integrates various signals, including nutrient availability, growth factors, and stress conditions, to regulate key biological processes. Dysregulation of mTOR signaling has been implicated in numerous diseases, including cancer, obesity, and metabolic disorders. Research on RPTOR is particularly pertinent as it serves as a critical adaptor protein that bridges mTOR complex 1 (mTORC1) to other signaling molecules, thus influencing mTORC1 activity and stability. Studying RPTOR and its interactions can provide insights into the molecular mechanisms underlying diseases and may uncover potential therapeutic targets. Given its integral role in modulating mTORC1 functions, RPTOR has gained attention in recent years, prompting extensive investigations into its structural properties, regulatory mechanisms, and interaction networks. As a result, the characterization of RPTOR as a recombinant protein has become a focal point of research, aiding in the understanding of its biological significance and potential as a drug target. Understanding RPTOR’s function and mechanism is essential for developing innovative therapeutic strategies that could tackle mTOR-related diseases more effectively.
