Analytical Data
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基因名
GAB2
- Application
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别名
pp100; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Z1S8
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表达区间
Gln357~Asp607
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分子量
31kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GAB2 (GRB2-associated binding protein 2) is an adaptor protein that plays a critical role in various cellular processes, including signal transduction, cell proliferation, and differentiation. It is known to interact with several growth factor receptors, such as the epidermal growth factor receptor (EGFR) and insulin receptor, linking these receptors to downstream signaling pathways. Research on GAB2 has gained momentum due to its involvement in various cancers, where its overexpression correlates with tumor aggressiveness and poor prognosis. In particular, the study of GAB2’s role in oncogenic signaling has revealed its potential as a therapeutic target. The recombinant expression of GAB2 allows for the detailed analysis of its structure, function, and interactions with other proteins. This can provide valuable insights into the molecular mechanisms underlying cell signaling and cancer progression. Additionally, understanding how GAB2 is regulated within cellular contexts may lead to novel strategies for intervention in diseases driven by aberrant signaling. Overall, the recombinant study of GAB2 is foundational for elucidating its roles in health and disease, making it a promising focus for future research in cancer biology and therapeutic development.
