Analytical Data
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基因名
PIKFYVE
- Application
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别名
PIP5K3; CFD; PIP5K; PIKfyve; p235; Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase,Type III; 1-phosphatidylinositol 3-phosphate 5-kinase
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Z1T6
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表达区间
Thr1725~Glu1976
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIKFYVE, a phosphoinositide-5-kinase, is an essential enzyme that plays a pivotal role in lipid signaling and membrane dynamics. Research on PIKFYVE has gained momentum due to its implications in various cellular processes, including endocytosis, autophagy, and neuronal signaling. It is particularly noteworthy for its involvement in the synthesis of phosphoinositides, which are critical for cellular signaling pathways and membrane trafficking. Dysregulation of PIKFYVE has been linked to several diseases, such as cancer and neurodegenerative disorders, making it a potential target for therapeutic intervention. The study of recombinant PIKFYVE has become increasingly important for dissecting its biochemical properties, identifying binding partners, and understanding its functional mechanisms in cellular contexts. By producing PIKFYVE as a recombinant protein, researchers can perform in vitro assays to study its enzymatic activity and interactions with various substrates and regulators. This research not only aids in elucidating the physiological roles of PIKFYVE but also helps in the development of inhibitors that could serve as novel therapeutic agents. The ongoing investigation around PIKFYVE underscores its significance in cell biology and its potential as a drug target, paving the way for advancements in understanding and treating diseases associated with its dysfunction.
