Analytical Data
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Gene name
NOD1
- Application
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Alternative Names
CARD4; CLR7.1; NLRC1; Caspase Recruitment Domain Family,Member 4; Nucleotide-Binding Oligomerization Domain,Leucine Rich Repeat And CARD Domain Containing 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y239
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Expression Region
Ala612~Asp826
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOD1 (nucleotide-binding oligomerization domain-containing protein 1) is a crucial component of the innate immune system, primarily recognized for its role in detecting bacterial peptidoglycans. As a cytosolic receptor, NOD1 activates signaling pathways that lead to the production of pro-inflammatory cytokines, thereby playing a vital role in host defense against infections. The study of NOD1 and its recombinantly expressed proteins has gained significant interest due to their therapeutic potential in modulating immune responses and enhancing vaccine efficacy. Researchers have been particularly focused on understanding the molecular mechanisms underlying NOD1 activation and its interaction with various bacterial components. Moreover, the ability to produce recombinant NOD1 proteins allows for the exploration of structure-function relationships and the development of novel immunotherapeutic strategies. By investigating NOD1 protein structure, researchers aim to identify key domains responsible for ligand binding and downstream signaling, which could pave the way for targeted interventions in immune-related disorders. Overall, NOD1 research represents a promising area in immunology, contributing to the development of innovative approaches to manage both infectious diseases and inflammatory conditions.
