Analytical Data
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Gene name
HES1
- Application
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Alternative Names
HHL; HRY; BHLHB39; HL; Class B basic helix-loop-helix protein 39; Hairy-like protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14469
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Expression Region
Val21~Asn251
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HES1, a member of the basic helix-loop-helix (bHLH) family of transcription factors, plays a crucial role in the Notch signaling pathway, which is vital for cell differentiation, proliferation, and development. This protein is particularly important in the context of various biological processes, including stem cell maintenance and the regulation of tissue homeostasis. Aberrant HES1 expression has been linked to several pathological conditions, such as cancer, where it often contributes to tumorigenesis through the modulation of cell cycle progression and apoptosis. The study of HES1 recombinant protein is essential for understanding its functional mechanisms and biological significance. By producing and isolating recombinant HES1, researchers can investigate its structural properties, binding interactions, and downstream effects on gene expression. Such studies have the potential to uncover novel therapeutic targets in diseases associated with dysregulated Notch signaling, emphasizing the importance of HES1 in both fundamental biology and clinical applications. The ability to manipulate HES1 and study its functional roles could lead to advances in regenerative medicine, cancer therapy, and the development of strategies to combat diseases where the Notch pathway is disturbed.
