Analytical Data
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Gene name
POT1
- Application
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Alternative Names
hPot1; POT1-like telomere end-binding protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NUX5
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Expression Region
Met1~Ala177
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POT1 (Protection of Telomeres 1) is a critical protein involved in the maintenance of telomere integrity, playing a vital role in preventing genomic instability during cell division. Telomeres, the protective end caps of chromosomes, shorten with each cell division, and their erosion is linked to aging and various diseases, including cancer. POT1 specifically binds to the single-stranded telomeric DNA, providing protection against exonucleases and preventing the activation of the DNA damage response. Research has shown that mutations or dysregulation of POT1 can lead to telomere dysfunction, contributing to tumorigenesis. The understanding of POT1's structure and function has profound implications for cancer biology, as it may serve as a potential therapeutic target. Recent studies focus on elucidating the molecular mechanisms by which POT1 interacts with other telomeric proteins and DNA, as well as its role in telomerase regulation. Investigating the functional consequences of POT1 alterations not only enhances our understanding of telomere biology but also paves the way for novel strategies in cancer treatment and potentially offers insights into aging processes. Understanding POT1's role and regulation is essential for developing therapeutics that could manipulate telomere length and function, potentially delaying the onset of age-related diseases and improving cancer therapies.
