Analytical Data
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Gene name
YWHAz
- Application
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Alternative Names
KCIP-1; 14-3-3-zeta; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63104
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Expression Region
Met1~Asn245
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
YWHAZ (Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) is a member of the 14-3-3 protein family, which plays critical roles in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction. Research into YWHAZ has gained traction due to its involvement in several diseases, particularly cancer, where it is often overexpressed and correlates with poor prognosis. The protein is known to interact with numerous signaling molecules, aiding in the stabilization and localization of client proteins, thereby influencing their activity. The modulation of these pathways highlights its potential as a therapeutic target. Furthermore, studies have shown that YWHAZ can affect cellular responses to stress and contributes to the regulation of metabolism in different cell types. Understanding the structure and function of YWHAZ through recombinant protein studies can provide valuable insights into its molecular mechanisms and interactions. This research aims to elucidate the protein's role in health and disease, paving the way for the development of novel interventions targeting YWHAZ in pathological conditions. The advancements in recombinant protein technology allow for more detailed structural and functional analysis, ultimately contributing to the broader understanding of the regulatory networks in which YWHAZ is involved.
