Analytical Data
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基因名
LDB1
- Application
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别名
CLIM2; NLI; Carboxy Terminal LIM Domain Protein 2; LIM domain-binding factor CLIM2; Nuclear LIM interactor
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86U70
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表达区间
Asp112~Gln411
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分子量
43kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LDB1 (LIM domain-binding protein 1) is a crucial transcriptional co-regulator that plays an essential role in various developmental processes and cellular functions, particularly in hematopoiesis and neural differentiation. Its primary function is to modulate gene expression by forming complexes with various DNA-binding transcription factors, enabling the precise regulation of target genes. Research into LDB1 has gained traction due to its implications in developmental disorders and cancers, where its dysregulation may contribute to abnormal cell differentiation and proliferation. Understanding the structural and functional dynamics of LDB1 through recombinant protein studies can provide insights into its mechanistic roles in transcriptional regulation. By expressing LDB1 as a recombinant protein, researchers can elucidate its interacting partners, target genes, and regulatory pathways. This research is further enhanced by employing advanced techniques such as cryo-electron microscopy and mass spectrometry, which allow for detailed analysis of protein complexes. Overall, the study of LDB1 and its recombinant forms represents a promising avenue for uncovering the complexities of gene regulation and its implications in health and disease.
