Analytical Data
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Gene name
CHAF1B
- Application
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Alternative Names
CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7; M-Phase Phosphoprotein 7; Chromatin Assembly Factor I,p60 subunit; M-phase phosphoprotein 7
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9D0N7
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Expression Region
Met1~Asn199
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHAF1B, also known as Chromatin Assembly Factor 1 Subunit B, is a crucial protein involved in the assembly of chromatin during DNA replication and repair processes. It plays a significant role in maintaining genome stability by facilitating the incorporation of histones into newly synthesized DNA, thereby influencing chromatin structure and gene expression. Recent studies have highlighted the importance of CHAF1B in various cellular processes, including cell proliferation and differentiation, as well as its implications in cancer biology. Abnormal expression of CHAF1B has been linked to tumorigenesis, making it a potential biomarker and therapeutic target for certain cancers. Furthermore, understanding the molecular mechanisms behind CHAF1B function could provide insights into epigenetic regulation and chromatin dynamics. As research continues to focus on the role of chromatin remodelers in gene regulation, CHAF1B stands out due to its essential contributions to chromatin assembly, warranting further investigation into its structure-function relationships and its interactions with other proteins in the chromatin assembly pathway. This growing body of evidence underscores the need for detailed studies on the recombinant form of CHAF1B, which can enhance our understanding of its biological roles and potential implications in disease contexts.
