Analytical Data
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Gene name
CPSF1
- Application
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Alternative Names
CPSF160; Cleavage and polyadenylation specificity factor 160 kDa subunit
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q10570
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Expression Region
Met1~Leu300
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Molecular Weight
37kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CPSF1 (Cleavage and Polyadenylation Specificity Factor 1) is a vital protein involved in the post-transcriptional regulation of gene expression, particularly in the process of mRNA processing, polyadenylation, and transcription termination. As a component of the cleavage and polyadenylation machinery, CPSF1 plays a crucial role in determining mRNA stability and translation efficiency. Recent studies have highlighted its significance in various cellular processes including cell proliferation, differentiation, and response to stress. Additionally, dysregulation of CPSF1 has been linked to several pathological conditions, including cancer, where aberrant mRNA processing contributes to oncogenesis. The investigation of CPSF1, particularly through recombinant protein studies, is essential for understanding its precise molecular functions and interactions within the cellular context. Such research not only elucidates the biological pathways governed by CPSF1 but also opens new avenues for therapeutic interventions targeting mRNA processing mechanisms in disease states. As a result, recombinant CPSF1 protein is an important tool in both basic research and potential clinical applications, providing insights into the fundamental aspects of RNA biology and its implications in health and disease.
