Analytical Data
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Gene name
EPN1
- Application
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Alternative Names
EPS-15-Interacting Protein 1; EH domain-binding mitotic phosphoprotein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6I3
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Expression Region
Pro279~Gly437
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Molecular Weight
41kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPN1, or Epsin 1, is an important protein involved in various cellular processes, particularly in the endocytic pathway and membrane dynamics. This protein contains a highly conserved Epsin N-terminal Homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis. EPN1 is known to interact with clathrin and other proteins involved in vesicle formation, thus facilitating the internalization of receptors and nutrients into the cell. Research into EPN1's role has gained momentum due to its implications in several biological processes, including signal transduction, growth factor receptor recycling, and cellular response to stress. Furthermore, aberrant EPN1 function has been associated with various diseases, including cancer and neurodegenerative disorders, making it a potential target for therapeutic interventions. Understanding the structure and function of EPN1 at the molecular level can provide insights into its regulatory mechanisms and how its dysregulation could contribute to disease pathology. Recent studies emphasize the importance of EPN1 in modulating cellular signaling pathways and maintaining cellular homeostasis, underscoring the necessity for comprehensive research into its biochemical properties and functional roles in health and disease.
