Analytical Data
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Gene name
BLNK
- Application
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Alternative Names
BASH; BLNK-s; Ly57; SLP65; B-Cell Adapter Containing A SH2 Domain Protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8WV28
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Expression Region
Ser65~Thr314
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BLNK (Bcell linker protein) is crucial in B cell receptor signaling and immune response modulation. Research into BLNK recombinant proteins has intensified due to their potential applications in understanding immune disorders and developing therapies for autoimmune diseases and cancers. BLNK acts as a scaffold that facilitates the interaction between various signaling molecules, leading to the activation of downstream pathways essential for B cell development and function. Its dysregulation is linked to various pathologies, including B cell tumors and immunodeficiencies. By studying recombinant BLNK proteins, researchers aim to elucidate the mechanisms underlying B cell signaling pathways and to identify potential therapeutic targets. The generation of these proteins allows for the exploration of BLNK's structural and functional characteristics, which can provide insights into disease mechanisms and the development of novel immunotherapies. Moreover, recombinant BLNK proteins can serve as valuable tools for drug screening and validation of promising therapeutic candidates. Overall, the investigation of BLNK recombinant proteins is crucial in advancing the understanding of B cell biology and addressing significant health challenges related to the immune system.
