Analytical Data
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Gene name
NBL1
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简介
NBL1 protein, identified as a potential tumor suppressor gene in neuroblastoma, plays a crucial role in inhibiting cells from progressing into the critical G1/S stage of the transformation process. Functioning as a homodimer, NBL1 underscores its involvement in regulatory mechanisms governing cellular transformation and emphasizes its potential contributions to maintaining normal cellular growth control. NBL1 Protein, Human (HEK293, Fc) is the recombinant human-derived NBL1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Neuroblastoma suppressor of tumorigenicity 1; Protein N03; NBL1; DAN; DAND1
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41271
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Expression Region
A17-D181
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Protein Length
Full Length of Mature Protein
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Molecular Weight
55-60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NBL1, also known as neublastin or NBL1 protein, is a member of the nerve growth factor (NGF) family and plays a crucial role in the development and maintenance of the nervous system. It has been implicated in various cellular processes, including neurogenesis, cell survival, and differentiation. Research has shown that NBL1 is involved in the regulation of neuronal growth and axon pathfinding, making it a significant focus in the field of neurobiology. Additionally, NBL1 has been linked to various pathological conditions, including neurodegenerative diseases and certain types of cancer, highlighting its potential as a therapeutic target. The recombinant production of NBL1 allows for the exploration of its structure-function relationship and provides a platform for investigating its biological activities in vitro and in vivo. Understanding the mechanisms through which NBL1 operates can reveal critical insights into neuronal function and repair, potentially leading to innovative strategies for treating neurological disorders. Therefore, ongoing studies aimed at characterizing NBL1 and its interactions with other cellular components are essential for advancing our knowledge in both developmental biology and therapeutic development.
