Analytical Data
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基因名
Podoplanin
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简介
Podoplanin plays a crucial role in cell migration and adhesion by interacting with various partners. It promotes platelet activation and aggregation by binding to CLEC1B, but attenuates platelet aggregation and lung metastasis by interacting with CD9. Podoplanin Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived Podoplanin protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
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别名
Podoplanin; Aggrus; Glycoprotein 36; Gp36; T1-Alpha; T1A; PDPN; GP36
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q62011
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表达区间
M1-L141
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蛋白长度
Partial
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分子量
60-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Podoplanin is a type I transmembrane glycoprotein that plays a crucial role in a variety of physiological and pathological processes, particularly in the development of lymphatic vessels and the promotion of tumor metastasis. It is primarily expressed in lymphatic endothelial cells and some tumor cells, where it is involved in cell migration, tissue remodeling, and immune response regulation. Given its significant role in cancer progression and metastasis, podoplanin has emerged as an important biomarker and therapeutic target in oncology. Research on recombinant podoplanin proteins has been increasingly focused on understanding its molecular mechanisms, interactions with other proteins, and potential applications in immunotherapy and cancer treatment. The production of recombinant podoplanin allows for detailed structural and functional studies, enabling researchers to explore its role in cell signaling pathways and its interactions with the immune system. Furthermore, recombinant podoplanin may serve as a candidate for vaccine development or as a tool for targeted drug delivery systems. Overall, the study of recombinant podoplanin proteins holds great promise for advancing our understanding of its role in disease and enhancing therapeutic strategies against cancer and lymphatic diseases.
