Analytical Data
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Gene name
Podoplanin
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简介
Podoplanin plays a crucial role in cell migration and adhesion by interacting with various partners. It promotes platelet activation and aggregation by binding to CLEC1B, but attenuates platelet aggregation and lung metastasis by interacting with CD9. Podoplanin Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived Podoplanin protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
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Alternative Names
Podoplanin; Aggrus; Glycoprotein 36; Gp36; T1-Alpha; T1A; PDPN; GP36
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Species
Mouse
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Source
HEK293
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Tag
C-hFc;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q62011
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Expression Region
M1-L141
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Protein Length
Partial
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Molecular Weight
60-65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Podoplanin is a type I transmembrane glycoprotein that plays a crucial role in a variety of physiological and pathological processes, particularly in the development of lymphatic vessels and the promotion of tumor metastasis. It is primarily expressed in lymphatic endothelial cells and some tumor cells, where it is involved in cell migration, tissue remodeling, and immune response regulation. Given its significant role in cancer progression and metastasis, podoplanin has emerged as an important biomarker and therapeutic target in oncology. Research on recombinant podoplanin proteins has been increasingly focused on understanding its molecular mechanisms, interactions with other proteins, and potential applications in immunotherapy and cancer treatment. The production of recombinant podoplanin allows for detailed structural and functional studies, enabling researchers to explore its role in cell signaling pathways and its interactions with the immune system. Furthermore, recombinant podoplanin may serve as a candidate for vaccine development or as a tool for targeted drug delivery systems. Overall, the study of recombinant podoplanin proteins holds great promise for advancing our understanding of its role in disease and enhancing therapeutic strategies against cancer and lymphatic diseases.
