Analytical Data
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Gene name
PIGR
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简介
PIGR proteins play a critical role in mediating the selective transcytosis of polymerized IgA and IgM across mucosal epithelial cells, which is critical for mucosal immunity. PIGR binds these immunoglobulins at the basolateral surface, forming a complex that is transported intracellularly and secreted apically. PIGR Protein, Human (G365S, HEK293, His) is the recombinant human-derived PIGR protein, expressed by HEK293 , with C-His labeled tag and G365S mutation.
- Application
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Alternative Names
Polymeric Immunoglobulin Receptor; Poly-Ig Receptor; PIGR
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01833
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Expression Region
K19-R638, G365S
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Protein Length
Extracellular Domain
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIGR (Polymeric Immunoglobulin Receptor) is a crucial protein involved in the transport of immunoglobulin A (IgA) and immunoglobulin M (IgM) across epithelial cells, playing a vital role in mucosal immunity. Research into PIGR has gained momentum due to its significant implications in understanding immune responses, particularly in mucosal surfaces such as the gut, respiratory tract, and other secretory systems. Dysregulation of PIGR is associated with various diseases, including autoimmune disorders, inflammatory diseases, and certain types of cancer, making it an attractive target for therapeutic intervention. The recombinant version of PIGR allows for detailed studies on its structural and functional properties, enabling scientists to explore the mechanisms of antibody transportation and secretion. Furthermore, recombinant PIGR can be employed in the development of novel vaccines and immunotherapies, enhancing the effectiveness of immune responses. As researchers continue to unravel the complexity of PIGR interactions and its role in health and disease, the exploration of recombinant proteins holds promise for advancing our understanding of mucosal immunity and developing innovative strategies against mucosal pathogens.
