Analytical Data
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Gene name
PTPRC/CD45R0
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简介
Receptor-type tyrosine-protein phosphatase C (PTPRC) is a receptor type PTP and an essential positive regulator of T- and B-cell antigen receptor signaling. PTPRC functions through direct interaction with antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. PTPRC also suppresses JAK kinases as a regulator of cytokine receptor signaling. PTPRC/CD45R0 Protein, Human (HEK293, Fc) is the recombinant human-derived PTPRC/CD45R0 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08575-4
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Expression Region
Q26-K416
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AA Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAviSTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK
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Protein Length
Partial
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Molecular Weight
122 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPRC, also known as CD45, is a crucial receptor-type protein tyrosine phosphatase that plays a vital role in regulating immune system functions, particularly in T and B lymphocytes. The CD45R0 isoform, in particular, is expressed on memory T cells and plays a significant role in their activation and differentiation. Understanding the structural and functional characteristics of PTPRC/CD45R0 is essential for elucidating its mechanisms in adaptive immunity and potential therapeutic applications. Research has shown that dysregulation of CD45 is associated with various autoimmune diseases, cancers, and immune deficiencies, making it a critical target for therapeutic intervention. Recent advances in recombinant protein technology have enabled the production of functional CD45R0 proteins, providing invaluable tools for studying its role in immune signaling pathways and cell interactions. These recombinant proteins can be utilized for antibody production, receptor signaling studies, and drug development, contributing to our understanding of immune responses and the development of novel therapies for immune-related disorders. The exploration of PTPRC/CD45R0 at the molecular level, therefore, holds promise for advancing our knowledge in immunology and enhancing clinical approaches to treat immune-mediated diseases.
