Analytical Data
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Gene name
EXOSC4
- Application
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Alternative Names
RRP41; RRP41A; Rrp41p; SKI6; Ski6p; hRrp41p; p12A; Ribosomal RNA-processing protein 41
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPD3
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Expression Region
Met1~Asp245
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EXOSC4, a crucial component of the exosome complex, plays a significant role in RNA processing and degradation, influencing various cellular processes such as gene regulation and RNA quality control. Research into EXOSC4 has become increasingly important due to its involvement in fundamental cellular mechanisms and potential links to various diseases, including cancer and neurodegenerative disorders. As a member of the exosome complex, EXOSC4 is responsible for maintaining RNA homeostasis and is implicated in the regulation of mRNA turnover and the processing of non-coding RNAs. Recent studies have highlighted its importance in specific cellular pathways, suggesting that dysregulation of EXOSC4 may contribute to pathophysiological conditions. The exploration of EXOSC4 as a target for therapeutic intervention is gaining traction, as understanding its biochemical properties and functional interactions could pave the way for novel strategies in treating diseases associated with RNA metabolism. Thus, the investigation of recombinant EXOSC4 protein not only enhances our understanding of the exosome complex's role in RNA biology but also presents opportunities for clinical advancements in the management of RNA-related disorders.
