Analytical Data
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基因名
EXOSC4
- Application
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别名
RRP41; RRP41A; Rrp41p; SKI6; Ski6p; hRrp41p; p12A; Ribosomal RNA-processing protein 41
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPD3
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表达区间
Met1~Asp245
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC4, a crucial component of the exosome complex, plays a significant role in RNA processing and degradation, influencing various cellular processes such as gene regulation and RNA quality control. Research into EXOSC4 has become increasingly important due to its involvement in fundamental cellular mechanisms and potential links to various diseases, including cancer and neurodegenerative disorders. As a member of the exosome complex, EXOSC4 is responsible for maintaining RNA homeostasis and is implicated in the regulation of mRNA turnover and the processing of non-coding RNAs. Recent studies have highlighted its importance in specific cellular pathways, suggesting that dysregulation of EXOSC4 may contribute to pathophysiological conditions. The exploration of EXOSC4 as a target for therapeutic intervention is gaining traction, as understanding its biochemical properties and functional interactions could pave the way for novel strategies in treating diseases associated with RNA metabolism. Thus, the investigation of recombinant EXOSC4 protein not only enhances our understanding of the exosome complex's role in RNA biology but also presents opportunities for clinical advancements in the management of RNA-related disorders.
