Analytical Data
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Gene name
KCNIP3
- Application
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Alternative Names
CSEN; DREAM; KCHIP3; Calsenilin; Presenilin-Binding Protein,EF Hand Transcription Factor; DRE-antagonist modulator; A-type potassium channel modulatory protein 3
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9JM47
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Expression Region
Met1~Ile256
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNIP3, also known as KChIP3 (K+ Channel Interacting Protein 3), is a member of the KChIP family of proteins that play critical roles in the modulation of voltage-gated potassium channels, particularly the Kv4 family, which are essential for neuronal excitability and cardiac function. The study of KCNIP3 and its recombinant protein form has gained attention due to its involvement in various physiological processes and pathological conditions, including cardiac arrhythmias and neuronal disorders. Research has shown that KCNIP3 interacts with Kv4 channels to enhance their trafficking and stability at the cell membrane, thereby influencing action potential duration and excitability in both cardiomyocytes and neurons. Additionally, KCNIP3 has been implicated in synaptic plasticity, suggesting its potential role in learning and memory processes. The generation of recombinant KCNIP3 protein allows for detailed biochemical and biophysical analysis of its structure and function, enabling researchers to investigate its precise mechanisms of action, interaction with channels, and potential therapeutic targets. Furthermore, understanding KCNIP3's role could lead to novel approaches in treating diseases associated with dysregulated potassium channel function, highlighting the importance of continued exploration in this area of research.
