Analytical Data
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Gene name
BAI2
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简介
The BAI2 protein is an orphan G protein-coupled receptor involved in cell adhesion and possible cell-cell interactions. It activates the NFAT signaling pathway through the G protein GNAZ and contributes to transcriptional regulation. BAI2 Protein, Human (HEK293, hFc) is the recombinant human-derived BAI2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human C1qL3 is immobilized at 2 μg/mL can bind Biotinylated Recombinant Human BAI2. The ED50 for this effect is 82.33 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human C1qL3 is immobilized at 2 μg/mL can bind Biotinylated Recombinant Human BAI2. The ED50 for this effect is 82.33 ng/mL.
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Alternative Names
Adhesion G protein-coupled receptor B2; ADGRB2; Brain-specific angiogenesis inhibitor 2; BAI2
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O60241-3
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Expression Region
F21-D911
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Protein Length
Partial
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Molecular Weight
128-150 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAI2 (Brain-specific Angiogenesis Inhibitor 2) is a member of the BAI family of G protein-coupled receptors (GPCRs), which are primarily expressed in the brain and play significant roles in various neurological processes, including synaptic plasticity and neuroprotection. The interest in BAI2 research stems from its potential implications in neurodegenerative diseases, cancer, and other pathological conditions where angiogenesis and neuronal signaling are disrupted. Studies have shown that BAI2 can influence cellular adhesion, migration, and the survival of neurons, making it a critical player in maintaining the homeostasis of brain tissue. Furthermore, the protein is linked to the regulation of synaptic transmission and can impact receptor signaling pathways that are essential for cognitive function and memory. Given the lack of therapeutic interventions targeting BAI2, understanding its structure, function, and the mechanisms by which it exerts its effects is vital. Recent advances in recombinant protein technology have enabled researchers to produce and study BAI2 in detail, facilitating exploration of its potential as a therapeutic target. The ongoing research into BAI2 is expected to uncover new insights into its role in brain health and disease, potentially leading to novel clinical applications in treating neurodegenerative disorders, where altered signaling pathways significantly contribute to disease pathology.
