Analytical Data
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Gene name
Integrin alpha A1 beta 1
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简介
Integrin α-1/β-1 is a receptor for laminin and collagen that recognizes the proline hydroxylation sequence GFPGER within collagen. This integrin negatively regulates EGF-stimulated cell growth and forms a heterodimeric complex with beta-1 that interacts with the small GTPase RAB21. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha A1 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-200 kDa (ITGA1) & 100-115 kDa (ITGB1), respectively.
- Application
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Alternative Names
Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; Integrin alpha A1 β 1; alpha A1 β 1; β 1
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Species
Mouse
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3V3R4 (F29-P1141)&P09055-1
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Expression Region
Q3V3R4 (F29-P1141)&P09055-1 (Q21-D728)
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Molecular Weight
140-200 kDa (ITGA1) & 100-115 kDa (ITGB1)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha A1 beta 1, a member of the integrin family, plays a crucial role in cell adhesion, signaling, and communication within the extracellular matrix. This heterodimeric protein is composed of an alpha A1 subunit and a beta 1 subunit, which together facilitate interactions between cells and the surrounding matrix components, influencing numerous physiological processes, including tissue development, immune responses, and wound healing. The study of integrin alpha A1 beta 1 is particularly significant due to its implications in various pathologies, including fibrosis and cancer metastasis, where aberrant integrin signaling can lead to altered cell behavior and disease progression. Recombinant protein technology has emerged as a powerful tool for investigating the structure-function relationships of integrins, enabling the production of functional integrin alpha A1 beta 1 for biochemical assays, structural studies, and potential therapeutic applications. By understanding how this integrin mediates cell-matrix interactions, researchers aim to identify novel strategies for modulating integrin activity, which could lead to innovative treatments for diseases involving integrin dysregulation. This research not only enhances our fundamental understanding of cell biology but also paves the way for advancements in targeted therapies and regenerative medicine.
