Analytical Data
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Gene name
PRM1
- Application
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Alternative Names
CT94.1; Cancer/Testis Antigen Family 94,Member 1; Sperm protamine P1; Cysteine-rich protamine
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04553
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Expression Region
Ala2~His51
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Molecular Weight
37kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRM1, or protamine 1, is a protein primarily expressed in the male germ cells and plays a critical role in sperm chromatin packaging during spermatogenesis. This study of PRM1 recombinant protein has garnered interest due to its implications in fertility and reproductive health. As one of the protamines, PRM1 is essential for replacing histones in sperm cells, facilitating the compaction of DNA, which is vital for successful fertilization and embryonic development. Research has shown that abnormal expression or mutations in the PRM1 gene can lead to male infertility issues, making it a focal point for understanding reproductive disorders. Additionally, recombinant PRM1 can serve as a valuable tool in various biomedical applications, including gene therapy and assisted reproductive technologies, as it has the potential to improve sperm functionality. The production of recombinant PRM1 can also aid in elucidating its structural properties and interactions with other cellular components, providing insights into the mechanisms of sperm development and function. Thus, advancing our knowledge in this area is not only significant for addressing infertility but also for exploring therapeutic avenues that could enhance reproductive outcomes in clinical settings.
