Analytical Data
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Gene name
UQCRC1
- Application
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Alternative Names
QCR1; UQCR1; Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31930
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Expression Region
Asp260~Phe480
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Molecular Weight
25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UQCRC1, or Ubiquinol-cytochrome c reductase core protein 1, plays a crucial role in the mitochondrial electron transport chain, specifically within complex III. This enzyme is essential for cellular respiration and energy production, as it facilitates the transfer of electrons from coenzyme Q to cytochrome c, a critical step in ATP synthesis. Recent studies have highlighted UQCRC1's significance beyond energy metabolism, indicating its potential involvement in various pathological conditions, including neurodegenerative diseases, cancer, and metabolic disorders. The functional characterization of UQCRC1 and its interactions with other mitochondrial proteins are pivotal for understanding the mechanisms underlying mitochondrial dysfunction. Recombination and functional studies of UQCRC1 can provide insights into its regulatory roles and potential as a therapeutic target. Investigating UQCRC1's structure and function not only enhances our understanding of mitochondrial biology but also opens avenues for developing strategies to mitigate diseases linked to mitochondrial defects. Therefore, research on UQCRC1 recombinant protein is vital for elucidating its biological functions and therapeutic potential, emphasizing its relevance in both basic and applied biomedical research.
