Analytical Data
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Gene name
WNK1
- Application
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Alternative Names
HSN2; KDP; PHA2C; PRKWNK1; HSAN2; Protein Kinase,Lysine Deficient 1; Hereditary Sensory Neuropathy, Type II; Erythrocyte 65 kDa protein; Kinase deficient protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H4A3
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Expression Region
Lys1954~Ala2231
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WNK1 (With No K (Lys) 1) is a serine/threonine kinase that plays a critical role in regulating various physiological processes, including blood pressure and ion homeostasis. Dysregulation of WNK1 has been associated with several pathological conditions, such as hypertension and genetic disorders like pseudohypoaldosteronism type II. This has spurred significant interest in understanding the structure, function, and mechanisms of action of WNK1. Research into recombinant WNK1 proteins has gained traction as scientists aim to decipher its signaling pathways and interactions with other cellular components. The production of WNK1 recombinant protein allows for in-depth investigations into its enzymatic activity, regulatory mechanisms, and potential as a therapeutic target. Moreover, studies utilizing WNK1 recombinant constructs facilitate the exploration of its role in cellular responses to stress and its implications in disease contexts, providing insights that could lead to novel interventions. By characterizing WNK1 at a molecular level, researchers are equipped to develop targeted therapies that may mitigate the effects of WNK1 dysregulation, thus enhancing our understanding of cardiovascular health and related disorders.
