Analytical Data
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Gene name
KDM4C
- Application
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Alternative Names
JMJD2C; JHDM3C; GASC1; Jumonji Domain Containing 2C; Gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3R0
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Expression Region
Leu685~Lys871
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KDM4C (lysine demethylase 4C) is a member of the Jumonji C-domain-containing family of histone demethylases, which play a crucial role in the regulation of gene expression and chromatin dynamics. It specifically targets trimethylated lysines on histone H3, particularly H3K9me3 and H3K36me3, thereby influencing various biological processes including cellular differentiation, proliferation, and response to stress. Alterations in KDM4C expression or activity have been associated with several pathological conditions, particularly cancer, where it may contribute to the epigenetic regulation of oncogenes and tumor suppressor genes. Research on KDM4C has gained momentum due to its potential as a therapeutic target; inhibitors of KDM4C are being explored for their ability to reverse aberrant gene expression patterns in malignant cells. Additionally, KDM4C's involvement in cellular processes such as DNA repair, the cell cycle, and stem cell maintenance highlights its significance in both normal physiology and disease pathology. Understanding the precise mechanisms through which KDM4C operates not only enhances our knowledge of epigenetic regulation but also opens new avenues for the development of targeted therapies in cancer and other disorders linked to dysregulated histone methylation. As such, ongoing studies aim to elucidate the functional implications of KDM4C in various biological contexts, paving the way for innovative therapeutic strategies that could leverage its role in the epigenetic landscape.
