Recombinant Human KDM4C Protein，His

KDM4C (lysine demethylase 4C) is a member of the Jumonji C-domain-containing family of histone demethylases, which play a crucial role in the regulation of gene expression and chromatin dynamics. It specifically targets trimethylated lysines on histone H3, particularly H3K9me3 and H3K36me3, thereby influencing various biological processes including cellular differentiation, proliferation, and response to stress. Alterations in KDM4C expression or activity have been associated with several pathological conditions, particularly cancer, where it may contribute to the epigenetic regulation of oncogenes and tumor suppressor genes. Research on KDM4C has gained momentum due to its potential as a therapeutic target; inhibitors of KDM4C are being explored for their ability to reverse aberrant gene expression patterns in malignant cells. Additionally, KDM4C's involvement in cellular processes such as DNA repair, the cell cycle, and stem cell maintenance highlights its significance in both normal physiology and disease pathology. Understanding the precise mechanisms through which KDM4C operates not only enhances our knowledge of epigenetic regulation but also opens new avenues for the development of targeted therapies in cancer and other disorders linked to dysregulated histone methylation. As such, ongoing studies aim to elucidate the functional implications of KDM4C in various biological contexts, paving the way for innovative therapeutic strategies that could leverage its role in the epigenetic landscape.