Analytical Data
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基因名
TITF1
- Application
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别名
TTF1; NKX2-1; BCH; BHC; NK-2; NKX2.1; NKX2A; TEBP; NK2 Homeobox 1; Benign Chorea; Thyroid nuclear factor 1; Thyroid-specific enhancer-binding protein
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43699
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表达区间
Ala40~Pro111
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分子量
41kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TITF1, also known as Thyroid Transcription Factor 1 (TTF-1), is a crucial transcription factor that plays a significant role in the development and function of the thyroid gland, lung, and certain regions of the brain. Its proper function is essential for the regulation of genes involved in thyroid hormone synthesis and pulmonary development. Research has shown that mutations or aberrant expression of TITF1 are associated with various diseases, including thyroid dysfunctions, lung cancers, and neurodevelopmental disorders. Due to its importance in cellular differentiation and organogenesis, the study of recombinant TITF1 protein has gained attention as a means to better understand its biological roles and potential therapeutic applications.
Recombinant TITF1 can be produced using various expression systems, enabling researchers to investigate its structure, function, and interactions with other proteins or transcriptional regulators. By conducting in vitro studies with purified TITF1 protein, scientists aim to elucidate its mechanisms of action in gene regulation and its implications in disease states. Furthermore, understanding the role of TITF1 in cellular processes may lead to innovative strategies for treating conditions linked to its dysfunction. Thus, the investigation of recombinant TITF1 not only provides insights into fundamental biological processes but also holds promise for the development of targeted therapies in endocrinology and oncology.
