Analytical Data
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Gene name
NKX6-1
- Application
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Alternative Names
NKX6A; Nkx6.1; NK6 Transcription Factor Related,Locus 1; Homeobox protein NK-6 homolog A
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78426
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Expression Region
Met1~Ser367
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Molecular Weight
68kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NKX6-1 is a key transcription factor that plays a crucial role in the development and function of pancreatic beta cells, which are responsible for insulin production. Dysregulation of NKX6-1 has been linked to various forms of diabetes, making it an important target for research in diabetes treatment and regenerative medicine. Studies have shown that NKX6-1 is essential for maintaining beta cell identity and function, as well as promoting beta cell proliferation and protection against apoptosis. The recombinant protein variant of NKX6-1 has been developed to explore its potential therapeutic applications, particularly in enhancing beta cell regeneration and improving insulin secretion. By using recombinant forms of NKX6-1, researchers aim to better understand its molecular mechanisms and interactions within beta cells, paving the way for innovative strategies to combat diabetes and restore normal insulin production in patients. This research holds promise not only for diabetes treatment but also for advancing our knowledge of pancreatic development and related metabolic disorders.
