Analytical Data
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基因名
BCAR1
- Application
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别名
CAS; CRKAS; P130Cas; CASS1; Crk-Associated Substrate; Cas Scaffolding Protein Family Member 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56945
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表达区间
Met1~Leu240
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCAR1, or Breast Cancer Anti-Estrogen Resistance 1, is a gene originally identified for its role in conferring resistance to anti-estrogen therapies in breast cancer cells. The BCAR1 protein has been implicated in various signaling pathways that regulate cell growth, survival, and motility, particularly in the context of cancer progression and metastasis. Its function relates to the integration of cellular responses to extracellular signals, making it a crucial player in tumor biology. Researchers have focused on the biochemical properties of BCAR1, exploring its interactions with other proteins and signaling molecules, which provide insights into cell survival mechanisms in hormone-resistant breast cancer. BCAR1 has also been studied for its potential as a therapeutic target, as inhibiting its function may enhance the efficacy of existing breast cancer treatments. The study of BCAR1 recombinant protein is essential to elucidate its mechanism of action and validate its potential as a biomarker for resistant breast cancer. Understanding the structure and function of this protein could lead to novel therapeutic strategies aimed at overcoming treatment resistance, ultimately improving patient outcomes in breast cancer management.
