Analytical Data
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Gene name
Stabilin-2
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简介
Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED50 for this effect is 0.09732 nM. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED50 for this effect is 0.09732 nM.
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8WWQ8
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Expression Region
G2198-V2295
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Protein Length
Partial
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Stabilin-2 is a multifunctional receptor primarily expressed in macrophages and other immune cells, playing a critical role in various physiological and pathological processes. This receptor is known for its ability to mediate endocytosis and clearance of apoptotic cells, pathogens, and other debris, thus contributing to tissue homeostasis and immune responses. The research on Stabilin-2 is driven by its potential implications in inflammation, autoimmune diseases, and cancer progression, where the receptor's activity may influence the immune environment and tumor microenvironment. Furthermore, understanding the molecular mechanisms underlying Stabilin-2 function could reveal novel therapeutic targets for modulating immune responses. Recent studies have focused on characterizing the structure, ligand interactions, and signaling pathways associated with Stabilin-2, which may provide insights into its regulatory roles in health and disease. Additionally, the development of recombinant Stabilin-2 proteins for experimental use could facilitate advanced research into its functions and interactions, paving the way for new strategies in treating diseases linked to dysregulated immune responses.
