Analytical Data
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基因名
PSMD14
- Application
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别名
26S proteasome regulatory subunit RPN11 (26S proteasome-associated PAD1 homolog 1) (POH1)
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种属
Human
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表达系统
Baculovirus
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标签
N- MBP & C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00487
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表达区间
1-310aa
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分子量
79.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD14, also known as the regulatory particle non-ATPase 14, is a vital component of the 26S proteasome, a complex responsible for degrading ubiquitin-tagged proteins within the cell. This proteolytic pathway is crucial for maintaining cellular homeostasis, regulating various biological processes, including cell cycle, signal transduction, and responses to oxidative stress. Dysregulation of proteasome activity, and by extension, PSMD14, has been implicated in various diseases, including cancer and neurodegenerative disorders. Recent studies have highlighted PSMD14’s role in modulating inflammation and immune responses, suggesting potential therapeutic targets for autoimmune diseases and cancer treatments. Research on PSMD14 recombinant protein provides important insights into its structural and functional characteristics, enhancing our understanding of its multifaceted roles in protein degradation and cellular regulation. As scientists continue to explore the mechanisms by which PSMD14 influences cellular processes, the potential for developing targeted treatments based on its modulation becomes increasingly promising, paving the way for innovative strategies in disease management and therapeutic interventions.
