Analytical Data
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Gene name
DAB2
- Application
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Alternative Names
DOC2; mitogen-responsive phosphoprotein; Differentially-expressed protein 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P98082
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Expression Region
Asn3~Thr129
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Molecular Weight
23kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAB2 (Disabled 2) is a multifunctional protein that plays a crucial role in various cellular processes, including endocytosis, signal transduction, and cellular differentiation. As a member of the disabled protein family, DAB2 is particularly important in the context of development and oncogenesis. Its expression is tightly regulated during embryonic development and is also implicated in various types of cancer, including breast, prostate, and ovarian tumors, where it may act as a tumor suppressor. The functional versatility of DAB2 arises from its interaction with different cellular partners and its involvement in critical pathways, such as those mediated by growth factors and hormones. Given its significance in cellular processes and disease, extensive research has focused on understanding the molecular mechanisms governing DAB2 function and regulation. The study of recombinant DAB2 proteins has enabled researchers to explore the structure-function relationships of this protein and to elucidate its role in signal transduction and tumor progression. By utilizing advanced techniques such as protein engineering, expression systems, and biochemical assays, scientists aim to clarify the functional domains of DAB2, identify its interacting partners, and assess its potential as a therapeutic target. Understanding DAB2's contributions to cellular dynamics and its implications in cancer biology continues to be a prominent area of investigation, with the hope of developing novel diagnostic and therapeutic strategies based on its molecular characteristics.
