Cat: IPD-X39143

Recombinant Human DAB2 Protein,His

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Analytical Data

  • 基因名

    DAB2

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    DOC2; mitogen-responsive phosphoprotein; Differentially-expressed protein 2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P98082

  • 表达区间

    Asn3~Thr129

  • 分子量

    23kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

DAB2 (Disabled 2) is a multifunctional protein that plays a crucial role in various cellular processes, including endocytosis, signal transduction, and cellular differentiation. As a member of the disabled protein family, DAB2 is particularly important in the context of development and oncogenesis. Its expression is tightly regulated during embryonic development and is also implicated in various types of cancer, including breast, prostate, and ovarian tumors, where it may act as a tumor suppressor. The functional versatility of DAB2 arises from its interaction with different cellular partners and its involvement in critical pathways, such as those mediated by growth factors and hormones. Given its significance in cellular processes and disease, extensive research has focused on understanding the molecular mechanisms governing DAB2 function and regulation. The study of recombinant DAB2 proteins has enabled researchers to explore the structure-function relationships of this protein and to elucidate its role in signal transduction and tumor progression. By utilizing advanced techniques such as protein engineering, expression systems, and biochemical assays, scientists aim to clarify the functional domains of DAB2, identify its interacting partners, and assess its potential as a therapeutic target. Understanding DAB2's contributions to cellular dynamics and its implications in cancer biology continues to be a prominent area of investigation, with the hope of developing novel diagnostic and therapeutic strategies based on its molecular characteristics.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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