Analytical Data
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Gene name
HRH4
- Application
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Alternative Names
GPCR105; GPRv53; H4R; HH4R; H4; AXOR35; BG26; G-protein coupled receptor 105
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3N8
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Expression Region
Trp90~Ala302
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRH4, or Histamine Receptor H4, is a G-protein coupled receptor primarily involved in regulating immune responses and inflammation. Discovered in the early 2000s, HRH4 has garnered significant attention due to its expression in various immune cells, such as mast cells, eosinophils, and dendritic cells. Unlike its counterparts, HRH1, HRH2, and HRH3, which are more widely studied in relation to allergy and neurobiology, HRH4's role in immunomodulation remains less understood, making it a compelling target for research. Studies have indicated that HRH4 activation can influence the production of cytokines and chemokines, thereby modulating the migration and function of immune cells, which is particularly relevant in conditions like asthma, allergic rhinitis, and autoimmune diseases. Additionally, the receptor's involvement in pain modulation and its potential influence on neuroinflammatory processes further underline its significance in health and disease. Consequently, the development of recombinant HRH4 proteins has become a priority for researchers seeking to elucidate its pharmacological properties, therapeutic potentials, and role in various pathophysiological conditions. By investigating HRH4 in detail, scientists aim to explore novel treatment strategies that leverage its immunoregulatory functions to improve outcomes in diseases characterized by excessive inflammation or immune dysregulation.
