Analytical Data
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Gene name
SESN1
- Application
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Alternative Names
SEST1; PA26; p53-regulated protein PA26
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P58006
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Expression Region
Gly45~Thr492
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Molecular Weight
56kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SESN1, or sestrin 1, is a multi-functional protein that plays a crucial role in cellular stress response, metabolism, and aging. It was initially identified as a protein that is upregulated in response to various stressors, including oxidative stress and nutrient deprivation. Research has shown that SESN1 acts as an important regulator of the mTOR pathway, which is a central hub for nutrient sensing and metabolic regulation. Dysregulation of the mTOR pathway is implicated in numerous diseases, including cancer, obesity, and neurodegenerative disorders. Additionally, SESN1 is thought to contribute to the modulation of autophagy, a cellular process responsible for degrading and recycling cellular components, thereby promoting cellular homeostasis. Given its diverse biological functions, SESN1 has garnered attention in the field of biomedical research, particularly as a potential therapeutic target for various age-related diseases. Investigating SESN1 recombinant protein allows researchers to delve deeper into its mechanisms of action, understand its role in cellular pathways, and explore its implications in health and disease. This area of research holds promise for developing novel strategies aimed at enhancing stress resistance and promoting longevity.
