Analytical Data
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Gene name
Amyloid Precursor/APP-751
- Application
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Alternative Names
Amyloid-beta precursor protein; APP; CVAP; PN-II; PreA4; A4; AD1
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Species
Human
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05067-8
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Expression Region
L18-M652
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Protein Length
Partial
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Molecular Weight
95-115 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of Amyloid Precursor Protein (APP) and its isoforms, particularly APP-751, has garnered significant attention in the context of Alzheimer's disease (AD) research. APP is a transmembrane protein that is crucial for neuronal growth, survival, and repair. It undergoes enzymatic cleavage by β-secretase and γ-secretase, leading to the production of amyloid-beta (Aβ) peptides, which aggregate to form plaques in the brains of AD patients. APP-751 is one of the alternative splicing variants of APP, which means it has unique structural and functional characteristics compared to other isoforms. Understanding the role of APP-751 is pivotal, as it may have distinct influences on Aβ production and cellular signaling pathways. Recent studies have shown that the expression levels of APP-751 can vary in different neuronal contexts, and its interactions with other proteins may modulate synaptic function and amyloidogenic processing. Investigating the recombinant forms of APP-751 can provide insights into its specific biological functions and contributions to neurodegenerative pathways, highlighting potential therapeutic targets for ameliorating AD progression. As research advances, the development of recombinant APP-751 can facilitate the exploration of the protein's role in AD pathology, enhancing our understanding of its involvement in amyloidogenesis and neuronal health.
