Analytical Data
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基因名
Amyloid Precursor/APP-751
- Application
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别名
Amyloid-beta precursor protein; APP; CVAP; PN-II; PreA4; A4; AD1
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05067-8
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表达区间
L18-M652
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蛋白长度
Partial
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分子量
95-115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of Amyloid Precursor Protein (APP) and its isoforms, particularly APP-751, has garnered significant attention in the context of Alzheimer's disease (AD) research. APP is a transmembrane protein that is crucial for neuronal growth, survival, and repair. It undergoes enzymatic cleavage by β-secretase and γ-secretase, leading to the production of amyloid-beta (Aβ) peptides, which aggregate to form plaques in the brains of AD patients. APP-751 is one of the alternative splicing variants of APP, which means it has unique structural and functional characteristics compared to other isoforms. Understanding the role of APP-751 is pivotal, as it may have distinct influences on Aβ production and cellular signaling pathways. Recent studies have shown that the expression levels of APP-751 can vary in different neuronal contexts, and its interactions with other proteins may modulate synaptic function and amyloidogenic processing. Investigating the recombinant forms of APP-751 can provide insights into its specific biological functions and contributions to neurodegenerative pathways, highlighting potential therapeutic targets for ameliorating AD progression. As research advances, the development of recombinant APP-751 can facilitate the exploration of the protein's role in AD pathology, enhancing our understanding of its involvement in amyloidogenesis and neuronal health.
