Analytical Data
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Gene name
HDAC11
- Application
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q91WA3
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Expression Region
Met1~Pro347
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Molecular Weight
43kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone deacetylase 11 (HDAC11) is a member of the histone deacetylase family, which plays a crucial role in epigenetic regulation by removing acetyl groups from histones, thereby influencing gene expression and cellular functions. Unlike other HDACs, HDAC11 exhibits unique characteristics, such as a distinct substrate preference and a limited expression pattern, making it a subject of interest in various biological processes. Recent studies have highlighted its involvement in immune responses, particularly in macrophage polarization and T cell differentiation, suggesting that HDAC11 may have therapeutic potential in autoimmune diseases and cancer. The development of recombinant HDAC11 proteins has facilitated research into its structure-function relationships and biochemical properties, enabling the exploration of specific inhibitors or modulators. Understanding the mechanisms by which HDAC11 exerts its effects could uncover novel strategies for therapeutic intervention. The ongoing research aims to elucidate not only the functional roles of HDAC11 in cellular contexts but also its interactions with other proteins and regulatory pathways, thereby contributing to our broader understanding of epigenetic regulation and its implications in health and disease.
