Analytical Data
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基因名
NT5C1A
- Application
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别名
Cytosolic 5'-nucleotidase IA ;cN-I ;cN-IA
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXI3
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表达区间
1-368aa
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分子量
43 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NT5C1A (Nucleotidase 5'-C1A) is an important enzyme involved in the hydrolysis of nucleotides, playing a key role in nucleotide metabolism and cellular signaling. It converts nucleoside monophosphates to nucleosides and inorganic phosphate, thus regulating levels of both nucleotides and nucleosides within the cell. Dysregulation of NT5C1A has been implicated in several pathological conditions, including cancer, where it contributes to the proliferation of tumor cells by modulating the nucleotide pool. The enzyme's expression levels and activity can influence cellular growth and survival, making it a potential target for therapeutic intervention. Research on NT5C1A has focused on its structural and functional properties, exploring the mechanisms underlying its enzymatic activity and its role in different cellular contexts. Additionally, the development of NT5C1A recombinant proteins allows for in-depth studies regarding its interactions with other cellular components, its regulatory mechanisms, and its potential as a biomarker for diseases. By understanding NT5C1A's function and regulation better, scientists aim to uncover novel strategies for treating disorders linked to nucleotide metabolism dysregulation.
