Recombinant Human CDC34 Protein，His

CDC34 is an essential gene involved in the regulation of the cell cycle, specifically in the context of ubiquitin-mediated protein degradation. It encodes an E2 ubiquitin-conjugating enzyme that plays a crucial role in the post-translational modification of proteins, facilitating their degradation via the proteasome. Research on CDC34 has been driven by its implications in various cellular processes, including apoptosis, DNA damage response, and signal transduction pathways. Aberrations in CDC34 expression or function have been linked to several diseases, particularly cancers, where dysregulated proteolysis can contribute to tumorigenesis. The study of CDC34 recombinant proteins allows researchers to investigate its enzymatic activity, substrate specificity, and interaction with E3 ligases, providing insights into the molecular mechanisms of cell cycle regulation and potential therapeutic targets. By employing recombinant techniques, scientists can elucidate the structural and functional characteristics of CDC34, paving the way for a better understanding of its role in maintaining cellular homeostasis and its impact on disease progression. This research is particularly relevant in the development of targeted therapies aimed at restoring normal cell cycle control in cancerous cells.