Analytical Data
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Gene name
RACGAP1
- Application
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Alternative Names
HsCYK-4; ID-GAP; MgcRacGAP; Male germ cell RacGap
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0H5
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Expression Region
Met106~Trp539
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Molecular Weight
78kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RACGAP1 (RAC GTPase-activating protein 1) is a critical regulator of the Rho GTPase family, particularly involved in the processes of cell division and cytokinesis. Its primary role is to facilitate the cleavage of RhoA-GTP, leading to the promotion of contractile ring formation during mitosis. Dysregulation of RACGAP1 has been implicated in various cancers, where it contributes to altered cell proliferation and invasion. Research has shown that RACGAP1 not only interacts with other key proteins involved in the mitotic machinery, such as CEP55 and ECT2, but it also plays a role in the signaling pathways that govern cellular responses to external stimuli. The production of recombinant RACGAP1 protein allows for the detailed study of its structural and functional aspects, aiding in elucidating its mechanism of action and its role in developmental processes and disease. Ongoing studies focus on the potential of RACGAP1 as a therapeutic target, highlighting the necessity for deeper understanding of its pathways and interactions in cancer biology and cell cycle regulation. The investigation of this protein's properties can pave the way for novel strategies in cancer treatment and provide insights into the fundamental processes of cell division.
