Analytical Data
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基因名
TIE-2
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简介
TIE-2 protein has growth factor binding activity and is involved in ossification, cAMP response, and estrogen response. It is predicted to be present in a variety of cellular components, as a component of the plasma membrane, and as part of receptor complexes. TIE-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; Tie2; VMCM
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种属
Rat
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
NP_001099207.1
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表达区间
A23-L743
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氨基酸序列
AMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFNHTDHFSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGGKML
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蛋白长度
Partial
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分子量
115-130 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIE-2, also known as angiopoietin receptor tyrosine kinase, plays a vital role in the regulation of vascular development and angiogenesis. It is primarily expressed in endothelial cells and is crucial for maintaining vascular homeostasis. Studies have shown that TIE-2 is involved in the signaling pathways that modulate blood vessel formation, stability, and integrity, making it a key player in both physiological and pathological conditions, including cancer, ischemia, and inflammatory diseases. The receptor binds to its ligands, angiopoietin-1 and angiopoietin-2, which regulate its activity and influence various biological processes. Research on TIE-2 has garnered interest due to its potential as a therapeutic target. Modulating TIE-2 activity may offer new strategies for treating diseases characterized by abnormal blood vessel formation. Furthermore, understanding the structural and functional properties of TIE-2, including its interactions with ligands and downstream signaling molecules, can provide insights into the mechanisms underlying vascular disorders. Consequently, TIE-2 recombinant protein studies are crucial for developing novel therapeutics aimed at regulating angiogenesis and improving outcomes in conditions like cancer, where tumor survival and growth depend on robust blood vessel formation. The continued exploration of TIE-2 and its pathways will enhance our understanding of vascular biology and may lead to innovative approaches for targeting angiogenesis in various diseases.
