Analytical Data
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Gene name
IQGAP1
- Application
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Alternative Names
HUMORFA01; SAR1; p195
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9JKF1
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Expression Region
Gln1276~Lys1657
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Molecular Weight
58kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IQGAP1 is a multi-domain scaffold protein that plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling pathways. It interacts with numerous proteins, such as actin, calmodulin, and Rho GTPases, which positions it as a key regulator of the cytoskeleton and cell morphology. Dysregulation of IQGAP1 has been implicated in various diseases, including cancer, where it contributes to tumor progression and metastasis by affecting cell motility and invasion. Given its significant role in cellular functions, researchers have focused on understanding the molecular mechanisms underlying IQGAP1's activity. The study of recombinant IQGAP1 protein allows for the detailed investigation of its structural and functional properties, including its binding interactions and effects on actin dynamics. By producing and characterizing this protein, researchers can explore its role in cellular signaling networks and identify potential therapeutic targets for diseases associated with abnormal IQGAP1 function. Ultimately, this research could provide insights into how manipulating IQGAP1 and its pathways may offer novel strategies for disease intervention, particularly in the context of cancer therapy.
