Analytical Data
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基因名
IQGAP1
- Application
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别名
HUMORFA01; SAR1; p195
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9JKF1
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表达区间
Gln1276~Lys1657
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分子量
58kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IQGAP1 is a multi-domain scaffold protein that plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling pathways. It interacts with numerous proteins, such as actin, calmodulin, and Rho GTPases, which positions it as a key regulator of the cytoskeleton and cell morphology. Dysregulation of IQGAP1 has been implicated in various diseases, including cancer, where it contributes to tumor progression and metastasis by affecting cell motility and invasion. Given its significant role in cellular functions, researchers have focused on understanding the molecular mechanisms underlying IQGAP1's activity. The study of recombinant IQGAP1 protein allows for the detailed investigation of its structural and functional properties, including its binding interactions and effects on actin dynamics. By producing and characterizing this protein, researchers can explore its role in cellular signaling networks and identify potential therapeutic targets for diseases associated with abnormal IQGAP1 function. Ultimately, this research could provide insights into how manipulating IQGAP1 and its pathways may offer novel strategies for disease intervention, particularly in the context of cancer therapy.
