Recombinant Human TDO Protein，His

TDO (Tryptophan 2,3-dioxygenase) is a key enzyme involved in the kynurenine pathway, which is crucial for tryptophan catabolism. The study of TDO recombinant protein has gained significant interest due to its role in regulating levels of tryptophan and its metabolites, important in various physiological and pathological processes. TDO is primarily expressed in the liver and is responsible for the oxidative cleavage of tryptophan into N-formylkynurenine, which further converts into kynurenine, linking it to immune response modulation, neurodegenerative diseases, and cancer. Abnormal TDO activity has been associated with increased kynurenine levels, leading to immunosuppression and potential tumor progression. Therefore, understanding TDO structure and function through recombinant protein production offers insights into its mechanistic roles in disease. Recent advances in molecular biology techniques have enabled the efficient production of TDO recombinant proteins, allowing for detailed characterization and the development of inhibitors that could mitigate its activity. This research may pave the way for therapeutic strategies targeting TDO to balance tryptophan metabolism in disorders linked to immune dysfunction and neurodegeneration. Overall, the exploration of TDO recombinant protein serves as a promising avenue for both fundamental research and clinical applications.