Analytical Data
-
Gene name
PPP6C
- Application
-
Alternative Names
PPP6; Serine/threonine-protein phosphatase 6 catalytic subunit
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O00743
-
Expression Region
Pro3~Leu239
-
Molecular Weight
38kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP6C (Protein Phosphatase 6 Catalytic Subunit C) is a member of the serine/threonine protein phosphatase family, which plays a crucial role in regulating various cellular processes including cell cycle progression, DNA damage response, and signal transduction pathways. It is particularly important in modulating the activity of key signaling proteins, thereby influencing cellular functions such as proliferation, differentiation, and apoptosis. The dysregulation of PPP6C has been implicated in several cancers and genetic disorders, making it a potential target for therapeutic intervention. Recent studies have highlighted its involvement in the regulation of the mTORC1 pathway, which is critical for cellular growth and metabolism. Given the significance of PPP6C in maintaining cellular homeostasis and its association with various pathological conditions, recombinant PPP6C proteins are being explored for their structural and functional properties. Understanding the biochemistry and molecular interactions of PPP6C can provide insights into its role in cellular signaling and disease, paving the way for novel treatment strategies. Research efforts have focused on characterizing the enzyme’s substrate specificity, inhibitor development, and its integration into broader cellular networks, all of which underscore the essential nature of this phosphatase in basic and translational research.
