Analytical Data
-
Gene name
PPP2R3a
- Application
-
Alternative Names
PPP2R3; PR130; PR72; Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Alpha; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q06190
-
Expression Region
Asp827~Glu1150
-
Molecular Weight
46kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP2R3A, or Protein Phosphatase 2 Regulatory Subunit B Alpha, is a critical component of the Protein Phosphatase 2A (PP2A) holoenzyme, which plays a vital role in numerous cellular processes, including cell cycle regulation, signal transduction, and apoptosis. Research has indicated that the dysregulation of PP2A activity contributes to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. The study of PPP2R3A is particularly important as it acts as a regulatory subunit that can influence the specificity and activity of PP2A, thereby modulating downstream signaling pathways. Recombinant PPP2R3A protein has been utilized for structural and functional studies, providing insights into its interactions with other cellular proteins, and revealing its potential role as a therapeutic target. Understanding the molecular mechanisms underlying its function and regulation can offer new avenues for developing treatments for diseases associated with PP2A dysfunction. Therefore, the generation and characterization of recombinant PPP2R3A are crucial for advancing our knowledge of its biological significance and potential clinical implications.
