Analytical Data
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基因名
PPP2R3a
- Application
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别名
PPP2R3; PR130; PR72; Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Alpha; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06190
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表达区间
Asp827~Glu1150
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分子量
46kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP2R3A, or Protein Phosphatase 2 Regulatory Subunit B Alpha, is a critical component of the Protein Phosphatase 2A (PP2A) holoenzyme, which plays a vital role in numerous cellular processes, including cell cycle regulation, signal transduction, and apoptosis. Research has indicated that the dysregulation of PP2A activity contributes to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. The study of PPP2R3A is particularly important as it acts as a regulatory subunit that can influence the specificity and activity of PP2A, thereby modulating downstream signaling pathways. Recombinant PPP2R3A protein has been utilized for structural and functional studies, providing insights into its interactions with other cellular proteins, and revealing its potential role as a therapeutic target. Understanding the molecular mechanisms underlying its function and regulation can offer new avenues for developing treatments for diseases associated with PP2A dysfunction. Therefore, the generation and characterization of recombinant PPP2R3A are crucial for advancing our knowledge of its biological significance and potential clinical implications.
