Analytical Data
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Gene name
CRTC1
- Application
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Alternative Names
MECT1; TORC1; WAMTP1; Target Of Rapamycin Complex; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UUV9
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Expression Region
Met1~Ser172
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Molecular Weight
25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRTC1 (cAMP-regulated transcriptional coactivator 1) is a critical player in various cellular processes, particularly those involved in metabolism and stress response. It serves as a key mediator in the cAMP signaling pathway, influencing gene expression by interacting with transcription factors such as CREB (cAMP response element-binding protein). Aberrant expression or mutations in CRTC1 have been linked to several diseases, including obesity and certain types of cancer, emphasizing its role in the regulation of energy balance and cellular growth. Recent studies have focused on understanding the functional mechanisms and interactions of CRTC1, as elucidating its structure and activity can provide insights into potential therapeutic targets. The need for CRTC1 recombinant proteins is paramount for such studies, facilitating detailed analyses of its biochemical properties, interaction partners, and post-translational modifications. By generating CRTC1 in a recombinant form, researchers can explore its structural biology and regulatory mechanisms, ultimately contributing to a better understanding of its role in health and disease. This research not only sheds light on fundamental biological processes but also paves the way for novel treatment strategies targeting CRTC1-related pathologies.
