Analytical Data
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Gene name
TCEA1
- Application
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Alternative Names
GTF2S; SII; TCEA; TF2S; TFIIS; Transcription elongation factor S-II protein 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23193
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Expression Region
Met1~Met228
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCEA1 (Transcription Elongation Factor A like 1) is a crucial protein involved in the regulation of gene expression through its role in transcription elongation. The importance of TCEA1 arises from its association with RNA polymerase II, where it facilitates the efficient progression of the enzyme along the DNA template during transcription. Recent studies have highlighted the role of TCEA1 in various cellular processes, including cell proliferation, differentiation, and response to stress, making it a significant target for understanding the underlying mechanisms of several diseases, including cancer. Notably, abnormalities in TCEA1 expression have been linked to tumorigenesis, indicating its potential as a biomarker for cancer progression and a possible target for therapeutic intervention. The production and study of recombinant TCEA1 protein provide a valuable tool for exploring its structure-function relationships and interactions with other molecular partners, aiding in deciphering its precise role in cellular biology. This research is further fueled by the demand for novel cancer treatments and the need for a deeper understanding of the transcriptional machinery in health and disease.
