Analytical Data
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Gene name
IRS2
- Application
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y4H2
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Expression Region
Ser985~Ala1255
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRS2 (Insulin Receptor Substrate 2) is a pivotal protein in the insulin signaling pathway, playing a crucial role in glucose homeostasis and energy metabolism. As a key adapter protein, IRS2 facilitates the transmission of signals from the insulin receptor to downstream pathways, including the PI3K/Akt pathway, which is integral for metabolic functions. Dysregulation of IRS2 has been linked to various metabolic disorders, including type 2 diabetes and obesity, highlighting its potential as a therapeutic target. Recent studies have shown that IRS2 is not only involved in insulin signaling but also has implications in cellular processes such as growth and differentiation. Researchers have been focusing on the recombinant expression of IRS2 to better understand its structural and functional characteristics. By producing IRS2 in a heterologous system, scientists can conduct in-depth functional assays and binding studies, unraveling its interactions with insulin receptors and other signaling molecules. This research is crucial for developing new strategies to enhance insulin sensitivity and address insulin resistance. Understanding the comprehensive role of IRS2 in metabolic pathways will contribute to devising novel interventions for metabolic diseases, underscoring the importance of ongoing studies of this protein.
